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2 edition of Bioassay of technical-grade bis(2-chlor-1-methylethyl) ether for possible carcinogenicity found in the catalog.

Bioassay of technical-grade bis(2-chlor-1-methylethyl) ether for possible carcinogenicity

National Cancer Institute (U.S.). Division of Cancer Cause and Prevention.

Bioassay of technical-grade bis(2-chlor-1-methylethyl) ether for possible carcinogenicity

by National Cancer Institute (U.S.). Division of Cancer Cause and Prevention.

  • 307 Want to read
  • 40 Currently reading

Published by Dept. of Health, Education, and Welfare, Public Health Service, National Institutes of Health in Bethesda, Md .
Written in English

    Subjects:
  • Carcinogens.,
  • Ether -- Toxicology.

  • Edition Notes

    StatementCarcinogenesis Testing Program, Division of Cancer Cause and Prevention, National Cancer Institute, National Institutes of Health.
    SeriesCarcinogenesis technical report series ; no. 191, DHEW publication ; no. (NIH) 79-1747, DHEW publication -- no. (NIH) 79-1747.
    ContributionsNational Institutes of Health (U.S.).
    The Physical Object
    Paginationxi, 84 p. :
    Number of Pages84
    ID Numbers
    Open LibraryOL18014813M

      In order to promote public education and public safety, equal justice for all, a better informed citizenry, the rule of law, world trade and world peace, this legal document is hereby made available on a noncommercial basis, as it is the right of all humans to know and speak the laws that govern them. Bioassay is a biochemical test to estimate the relative potency of a sample compound to a standard compound. Typical bioassay involves a stimulus (ex. drugs) applied to a subject (ex. animals, tissues, plants) and a response (ex. death) of the subject is triggered and measured.

      Addeddate Identifier Identifier-ark ark://t17m Ocr ABBYY FineReader Ppi home - products - services - order - distributors - support - career - contact us - BioAssay Systems is committed to producing innovative, high-quality and cost-effective products and to providing expert technical service to our valued customers.

      4. Bioassay Potency or concentration of an active principle in unit quantity of preparation by measuring its biological response on living tissues Introduced by Paul Ehrlich - biostandardization of Diphtheria antitoxin 4. 5. Synonyms 5 Biological assay Bio metrics Biological standadization Bio-standadizatio n. Quantics can help you to implement a monitoring protocol for your bioassay. Simple monitoring by plotting data over time may be adequate in development situations, but in GMP manufacturing regulators are starting to expect a more formal approach known .


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Bioassay of technical-grade bis(2-chlor-1-methylethyl) ether for possible carcinogenicity by National Cancer Institute (U.S.). Division of Cancer Cause and Prevention. Download PDF EPUB FB2

Bis(2-chloromethylethyl) ether is a beta-haloether and a byproduct of propylene oxide and propylene glycol manufacture. A bioassay of technical grade bis(2-chloromethylethyl) ether for possible carcinogenicity was conducted by administering the test chemical by gavage to F rats.

Groups of 50 rats of each. This book will be helpful for anyone working in aquatic environments or those who need an introduction to ecotoxicology or bioassays, from investigators, to technicians and students. Bioassay of Technical Grade Bis(2-chloromethylethyl) ether for Possible Carcinogenicity (CASRN ) Technical Report: TR PDF (4MB) Bioassay of Phenesterin for Possible Carcinogenicity (CASRN.

Chioce test bioassay with twospotted spider mite on treated (1% rosemary oil) and non-treated leaf discs 0 5 10 15 20 25 30 35 0 4 8 12 16 20 24 28 32 36 40 44 48 Time Number of mites Treated Control Repellence of spider mites by rosemary oil Leaf Disc Choice Bioassay 1.

Leaf area measured 2. Feeding deterrence: FD = * [(C-T)/(C+T)]File Size: KB. CHAPTER 8 BIOASSAY PROCEDURES BIOASSAY a. Bioassays are procedures which estimate the amount of radioactive material deposited in the body, either by direct measurement, using sensitive x-ray detectors placed over the chest (lung counting) and/ or other organs, or by detection of radioactivity in the excreta (feces and urine).File Size: 61KB.

operation of the bioassay program. (13) The test animals (if required for the bioassay) should be easily obtainable, easily handled, easily bred and resistant to infections.

(13) Finally the bioassay should be economical to conduct over extended time periods. A hit rate of 1% or less is generally considered a reasonable and one then proceeds fromFile Size: 1MB.

standards referencing this book - (show below) - (hide below) bis is (r) reagent grade water: bis is (r) double hessian jute bags for pesticides: bis is (r) methods of sampling for technical grade pesticides: bis is (r) specification for dw tarpaulin laminated jute bags for pesticides.

An emergency or priority bioassay specimen. A bioassay specimen that is collected as a result of a potential accidental exposure to radioactive material. Diagnostic bioassay specimen.

A follow-up specimen performed as soon as possible, but not later than 1 week, in order to confirm the initial result in the following cases:File Size: 1MB. Digitalis induced head drop in rabbits Calculation of LD50 in mice or rats [2] Graded Response Assays [mostly on tissues] Graded responses to varying doses Unknown dose response measured on same tissue Methods of Bioassay con1 [2] Graded Response Assays [ Direct comparison on same tissues] Interpolation: Conc.

of unknown is read from a standard. Bureau of Indian Standards maintained the thrust and dynamism and ex hibited an all round progress during the year It recorded an income of arou nd Rs crores during 1 April ± 31 December For the twenty sixth consecutive year, BIS met its recurring and non-plan expenditure from its o wn Size: KB.

Purchase Bioassay - 1st Edition. Print Book & E-Book. ISBNBook Edition: 1. Dioxathion, an organophosphorous insecticide, was selected for bioassay by the National Cancer Institute because of its widespread use on livestock and edible crops, and a lack of adequate chronic toxicity data.

A bioassay for possible carcinogenicity of technical-grade dioxathion was conducted using Osborne-Mendel and B6C3F1 mice.

Bureau of Indian Standards has appointed BSB Edge Private Limited for creation and functioning of e-Sale portal for sale of Indain Standards (IS) and Special Publications (SP) in soft copy and hard copy.

Therefore your request for purchase of these publications will be redirected to them by clcking the following link. Statistical analysis of biological assays Yossi Levy 2 What is a bioassay.

Bioassays are for estimating the potency of a drug by utilizing the reaction caused by its application to live experimental subjects. Bioassay always compares a test substance to a standard substance Assumptions Comparable organisms Same active compound Only.

] Design and Analysis for Bioassays 63 Preparations Tolerences mean Strophanthus A,(Test Prep.) The purpose of a bioassay is to discover equally effective doses of the standard and test preparations, that is to say, doses whose inverse ratio will estimate the potency of the File Size: KB.

Peroral bioassay of technical-grade preparations of the Douglas-fir tussock moth nucleopolyhedrosis virus (Baculovirus). Portland, Or.: Pacific Northwest Forest and Range Experiment Station, U.S.

Dept. of Agriculture, Forest Service,   This book presents a range of "bench top" bioassay techniques useful for natural product and pharmaceutical chemists involved in drug discovery and pharmacognosy. The contents detail a number of enzyme-based assays, cell-based functional bioassays and receptor radioligand binding assays along with detailed descriptions of each by: Bioassay of technical grade bis(2-chloromethylethyl) ether for possible carcinogenicity.

(Book, ) [] Get this from a library. Bioassay of technical grade bis(2-chloromethylethyl) ether for possible carcinogenicity. Bioassay is a procedure for the determination of the concentration of a particular constitution of a mixture [].

Structure of Biological Assay. The typical bioassay involves a stimulus applied to a subject. Application of stimulus is followed by a change in some measurable characteristic of the subject, the magnitude of the change being. Evidence on the Carcinogenicity of Technical Grade Bis(2-chloromethylethyl) ether.

in July At their October 7,meeting the Committee found, by a vote of six in favor and one against, that technical grade bis(2-chloromethylethyl) ether had been “clearly shownFile Size: KB.

STATISTICAL ANALYSIS OF RESULTS OF BIOLOGICAL ASSAYS AND TESTS 1. INTRODUCTION This chapter provides guidance for the design of bioassays prescribed in the European Pharmacopoeia (Ph. Eur.) and for analysis of their results. It is intended for use by those whose primary training and responsibilities are notFile Size: 1MB.

8. In vitro techniques: • These techniques employ a cell culture of recommended biological system to study the effect of compound under standard condition not similar to that of living environment. Here the cell culture survives by utilization of the nutrition in the media. • Ex: use of stem cells, cell culture, microbes (bacteria) etc.1.

Author(s): Hazleton Laboratories America.; National Institutes of Health (U.S.); Carcinogenesis Testing Program (U.S.) Title(s): Bioassay of technical-grade bis(2-chloromethylethyl) ether for possible carcinogenicity.